In this week’s InnovationRX edition, we look at the impact of the healthcare termination, the winners of the Nobel Prize in Medicine, the attempt to consume AMGEN and much more. To take it to your inbox, Sign up here.
HOspitals and Health Systems across the country tell some patients with Medicare and Medicaid that they I can’t schedule a telecommunication appointment Due to the termination of the federal government, it is now headed in the second week. This is due to the fact that Medicare’s return to Telehealth ended on September 30, leaving the health systems with his choice Pause such visits or maintaining them with the hope of retroactive compensation after the end of the termination.
Return for the Hospital Program at home, which allows patients to take care without being admitted to a hospital, also with the closure. That led to providers renovation to evacuate patients under the program or admit to a hospital. Mayo Clinic, for example, had to move about 30 patients from their homes in Arizona, Florida and Wisconsin to its premises.
The issue of government interruption is healthcare, in particular the tax credits for US medium and lower income that allow them to provide health insurance to federal exchanges created by law on accessible care. The Democrats want to extend these tax credits, which are to expire at the end of the year, while Republicans want to reopen the government first and then negotiate for tax credits in a final budget.
The impasse has prevented the Senate from surpassing a hospitable, despite the majority of Republicans. About 24 million Americans receive their health insurance through ACA and loss of tax credit will cause an average of 75% to increase their premiums – and 90% in rural areas – and will probably cause at least 4 million people to lose fully.
The closure of the government has resonated through its activities in health care. The Ministry of Health and Human Services has passed about 41% of its staff, making it harder to execute supervision operations. CDC’s lack of staff will prevents monitoring of threats to public health. And fda I will not accept Any new drug applications until funding is restored.
When the government can reopen it remains unclear. Most of the finishes are relatively short, but the longest, which lasted 35 days, came during Donald Trump’s first term. The leader of the Senate majority, John Thune, Rs.D., and a speaker at the house Mike Johnson, R-LA. They both have that they will not negotiate with the Democrats and the body will not meet again by October 14th. Players in polymers It is currently expected to last until at least October 15. Congress pressure will increase after this date because there will be no funds available to pay active military members.
Three researchers for autoimmune diseases win the Nobel Prize
Nobel Prize winners Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi
TT news agency/AFP via Getty Images
TScientists whose ideas can one day help in the treatment of autoimmune disorders won this year Nobel Prize in Medicine.
The winners, Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi will share the award of about $ 1.2 million to discover T-cell regulators, which prevent the immune system from attacking body tissues.
Sakaguchi, a professor at the University of Osaka, Japan, discovered these cells in 1995, upgrading the scientific consensus on how the immune system is regulated and opens a new understanding of how it works. Bruunkow, now senior director at the Seattle System Biology Institute, and Ramsdell, scientific adviser to Sonoma Therapeutics, was built on the discovery of Sakaguchi when they found a mutation in a gene called FOXP3 that made a very sensitive mouse stem in 2001.
Today, there are More than 200 clinical trials For drugs that use T-cells to treat a variety of autoimmune disorders and help prevent the rejection of organs after transplantation. In 2019, Ramsdell signed the Sonoma Biotherapeutics based in San Francisco for the development of T-cell-based regulators for rheumatoid arthritis and a chronic condition of the skin called Hidradenitis Suppuratitiva, both in Phase 1 tests.
‘Their discoveries were decisive for our understanding of how the immune system works And why we are not all developing serious autoimmune diseases, “said Olle Kämpe, chairman of the Nobel Commission.
Biotechnology and pharmacy
Co -founder of Moderna Bob Langer started a new biotechnology, Souffle Therapeuticswith funding of $ 200 million. Langer, Professor of MIT worth $ 1.2 billion Forbes, It has more than 1,400 patents and has co -existed dozens of companies, including SQZ, Seer and Sigilon Therapeutics biotechnologies. Souffle is planning to develop medicines using a type of RNA called Sirna that inhibits gene expression. The first treatments will focus on muscle dystrophies, heart failure and metabolic disorders. Langer’s daughter, Susan Langer, is the founding president of the company and CEO. Her CEO is Amir Nashat of Polaris Partners.
Plus: Astrazeneca’s possible new blood pressure drug, Baxdrostat has satisfied his goal of significantly reducing high blood pressure over 24 hours compared to a placebo in patients with resistant hypertension in late -stage clinical trial. The Anglo-Swedish pharmacist hopes the drug could produce up to $ 5 billion in annual sales once approved, helping it achieve the target of $ 80 billion by 2030.
Digital health and ai
Amgen will start Sale of medicines directly to the consumer for reduced cash prices, Starting from the restoration of cholesterol medicines, at a monthly price of $ 239 or 65% below its directory price. The move comes as Trump’s administration has pushed pharmaceutical companies to reduce drug prices and announced its own Trumprx location. Amgen released clinical trial data Last week This has shown that repatha significantly reduces the risk of heart attack in combination with statins.
Plus: Starting Australian Health Technology Heidi raised $ 65 million led by private investment Point72 in valuation of $ 465 million to accelerate the development of AI Scripbe technology.
Public health and hospitals
Pollution from climate by asthma inhalers has an impact of half a million cars a year, according to one Study published in Jama. Dose inhales, which are based on greenhouse gases also used in cooling and air conditioning, represented 98% of this pollution. Dr. William Feldman, a researcher of lung and health services in UCLA, who signed the study, told CNN that “it is one extremely stable problem“Due to the alternative products available today and in growth.
Plus: CDC manager Jim O’Neill asked the MMR vaccine against measles, mumps and reds to be broken in three separate shots– Despite the items are no safer or more effective. No such vaccine is currently available in the US and the delivery of each vaccine separately would require children to have Six injections instead of twowhich could lead to less vaccinated.
What do we read
Pfizer’s agreement with Trump to reduce drug prices has little impact on the lower line – but removes a lot of regulatory uncertainty. Investors adore it.
THE Er said to a college student It just had a virus. Days later, he was dead.
Women make up only 11% of Biopharma’s Managing Directors As the industry makes minimal progress in gender diversity.
Biotech Startup Kernal Biologics received a $ 48 million federal grant Develop the MRNA-based T-cell program against certain cancers.
The US Hospitals Association and FBI warned the healthcare providers using Oracle Software Correct a significant safety defect immediately This leaves them vulnerable to hackers.
Six former generals of surgeons, who served both Democratic and Democratic Administrations, warned that HHS Secretary Robert F. Kennedy, the policies of the younger, are a danger to public health, calling his policies and puts a “deep, immediate and unprecedented threat”.
The Supreme Court suggested that it could limit bans on LGBTQ convert therapy – at least as it is applied to speak treatment – during oral arguments in a case by questioning the prohibition of Colorado. More than 20 states have passed laws that prohibit or restrict conversion therapy, which repeated studies have shown that they have harmful effects on patients.
Online prescription drug delivery start Blinkrx -a Company associated with Donald Trump, Jr. – Stands for the benefit From his efforts to revise drug sales.
More than Forbes
